A Cluster to Remember Cell Biology Diagrams Classical regulators include the transcription factors E2F1 and FOXM1 that are required for the temporal control of gene expression in G1-S and G2-M stages of cell cycle, respectively 4,19,20,21
Evidence has supported a broad role for apoptosis-related genes in cell-cycle progression, possibly through direct regulation of the E2F class of transcription factors or other activities
resolution transcriptome map of cell cycle reveals novel ... Biology Diagrams
Among 3028 cell cycle associated genes, 2125 genes are validated targets of 424 microRNAs; CDKN1A is a target of 46 miRNAs and miR-335 targets 301 genes. About 100 transcription factors had binding sites at potential promoter regions of 2722 genes and 329 microRNAs that target cell cycle associated genes. We presented the largest numbers of
Many proteins that carry out important functions during the cell cycle display a cyclic expression pattern that is often regulated on the transcriptional level (13, 14).Because it has been shown that cell-cycle gene expression serves as a tumor signature (), extensive efforts have been devoted to identify periodically expressed genes across the cell cycle using microarray platforms (4, 16-20).
The E2F family: specific functions and overlapping interests Biology Diagrams
Cell cycle-dependent gene transcription is tightly controlled by the retinoblastoma (RB):E2F and DREAM complexes, which repress all cell cycle genes during quiescence. Cyclin-dependent kinase (CDK) phosphorylation of RB and DREAM allows for the expression of two gene sets. The first set of genes, with peak expression in G1/S, is activated by E2F transcription factors (TFs) and is required for
This work has revealed many new insights into how transcription of different G1-S cell cycle genes is restricted to G1 and how this is regulated by DNA replication checkpoint protein kinases as part of the checkpoint transcriptional response. Landman A, Futcher B. The G1 cyclin Cln3 promotes cell cycle entry via the transcription factor
